Metrogen Tablet Uses, Dosage, Precautions & Side Effects

What is Metrogen Tablet?

Metrogen Tablet is a prescription medicine that contains Metronidazole. It’s used to treat various infections caused by bacteria and parasites.

Metrogen Tablet is a highly effective medication used for several conditions, including:

  1. Symptomatic trichomoniasis (sexually transmitted infection)
  2. Asymptomatic trichomoniasis
  3. Amebiasis (parasitic infection of the colon)
  4. Giardiasis (parasitic infection of the small intestine)
  5. Anaerobic bacterial infections (intra-abdominal, skin, gynecologic, etc.)
  6. Prevention of infections related to elective colorectal surgery
  7. Treatment of acute dental infections, leg ulcers, and pressure sores

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The dosage of Metrogen Tablet, containing Metronidazole, varies depending on the specific condition being treated:

  1. For sexually transmitted infection (trichomoniasis):
    • Adult: 2000 mg as a single dose or 1000 mg in two divided doses on the same day or 250 mg three times a day for seven days.
    • Children (1 to 10 years): 40 mg/kg in a single dose or 15-30 mg/kg in a day divided into 2-3 doses, with a maximum of 2000 mg per dose.
  2. For parasitic infection of the colon (amebiasis):
    • Adult: 500 mg or 750 mg three times daily for 5 to 10 days.
    • Children: 35 to 50 mg/kg/day divided into three doses daily for 10 days.
  3. For anaerobic bacterial infections:
    • Adult: 7.5 mg/kg every six hours for 7 to 10 days, with a maximum of 4000 mg per day.
    • Children: Dosage based on weight.
  4. For bacterial overgrowth in the vagina (bacterial vaginosis):
    • Adult: 2000 mg as a single dose or 400 mg twice a day for 5 to 7 days.
  5. For parasitic infection of the small intestine (giardiasis):
    • Adult: 2000 mg once a day for 3 days or other regimens.
    • Children (various dosages based on age).
  6. For other specific conditions, including dental infections, leg ulcers, and Helicobacter pylori eradication, the dosage varies.

It’s essential to follow the prescribed dosage and duration recommended by your doctor. Dosage may be adjusted based on age, weight, health condition, and response to treatment.

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Side Effects

Common side effects of Metrogen Tablet (Metronidazole) include gastrointestinal discomfort such as nausea, vomiting, and diarrhea.

It may also cause a metallic taste in the mouth, headache, dizziness, and skin reactions like rash or itching. In rare cases, changes in blood cell counts or peripheral neuropathy (numbness or tingling) may occur.

Serious side effects are uncommon but may include severe abdominal pain or seizures. If you experience unusual symptoms, consult your healthcare provider promptly.

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Precautions & Warnings

  1. Allergies: Inform your doctor if you are allergic to Metronidazole or nitroimidazole antimicrobials.
  2. Medical History: Disclose your medical history, especially blood disorders, liver disease, kidney disease, or conditions like Crohn’s disease.
  3. Disulfiram Use: Avoid Metrogen if you have taken disulfiram in the last two weeks, as it may lead to mental problems.
  4. Pregnancy and Breastfeeding: Use only if necessary during pregnancy or breastfeeding under a doctor’s guidance.
  5. Older Adults: Exercise caution, and older patients may require monitoring for increased side effects.
  6. Liver Function Tests: Regular liver function tests are recommended, especially in patients with severe liver damage.
  7. Alcohol Consumption: Avoid alcohol during and after treatment, as it may lead to adverse reactions.
  8. Driving and Machinery: Be cautious while driving or operating machinery, as Metrogen can cause drowsiness.
  9. Side Effect Monitoring: Report symptoms like stomach pain, yellowing of the skin, or seizures promptly to your doctor.

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Drug Interactions

  1. Warfarin: Increases bleeding risk; monitor closely.
  2. Lithium: Raises lithium levels; monitor carefully.
  3. Phenytoin: May increase phenytoin levels; watch for toxicity.
  4. Alcohol: Avoid during and 48 hours after Metronidazole treatment.
  5. Cimetidine: May increase Metronidazole levels; adjust dose if needed.
  6. Busulfan: Can enhance busulfan toxicity; avoid together.
  7. Anticoagulants: Raises bleeding risk with oral anticoagulants.
  8. Disulfiram: Avoid; may cause psychotic reactions.
  9. Lopinavir/Ritonavir: Monitor for adverse effects; levels may increase.
  10. Rifampicin: Reduces Metronidazole efficacy; consider alternatives.
  11. Phenobarbital: May decrease phenobarbital levels; adjust dosage.
  12. Cyclosporine: Watch for increased cyclosporine levels; monitor for toxicity.

Inform your doctor & pharmacist about all medications and supplements to prevent potential interactions.

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Use in Pregnancy

  • Pregnancy Category: Generally safe during pregnancy.
  • Talk to Doctor: Discuss with healthcare provider.
  • First Trimester Caution: Be cautious, especially in early pregnancy.
  • Explore Alternatives: Consider other options if available.
  • Inform Provider: Share pregnancy status with healthcare provider.
  • Individual Assessment: Evaluate risks and benefits for your situation.
  • Regular Monitoring: Keep track of maternal and fetal health.

Frequently Asked Questions

What is Metrogen Tablet used for?

Metrogen treats infections like trichomoniasis, anaerobic bacterial infections, and parasitic infections in the colon and small intestine.

How should I take Metrogen?

Follow your doctor’s advice, swallow it with water, and avoid chewing. The dosage and duration depend on your condition.

What if I miss a dose?

Take it as soon as you remember. If it’s close to the next dose, skip the missed one.

Can I drive after taking Metrogen?

Be cautious; it may cause dizziness or drowsiness.

How long does Metrogen take to work?

The duration varies based on the infection. Follow the full course prescribed by your doctor.